In many respects, drug delivery is the perfect field for an organic chemist whose interest is in structure-property relationships; synthesis and characterization of a drug delivery system and subsequent introduction of this drug delivery vehicle into animals or humans is a complex and challenging structure-property problem. In this regard, we developed hydroxybutenyl cyclodextrin (HBenCD) for oral and intravenous delivery of pharmaceutical actives having poor water solubility and low bioavailability. In this presentation, we describe the synthesis and characterization of HBenCD, formation of drug-HBenCD complexes, in vitro solubility and dissolution studies of drug-HBenCD complexes, and pharmacokinetic studies in animals after oral and intravenous administration of drug-HBenCD complexes.

Building drug delivery systems: In vitro and in vivo studies of drug-hydroxybutenyl cyclodextrins complexes

255th National Meeting (2018)

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