The self-assembly of amphiphilic di-block copolymers into polymeric vesicles, commonly known as polymersomes, is an area of high interest in research due to the potential applications in the field of drug delivery. Polymersomes are fully synthetic robust vesicles composed of a hydrophobic membrane and a hydrophilic core, providing the ability for stable dual-encapsulation of a variety of molecules. Methods have been developed for triggered encapsulant release using ultrafast, single-pulse irradiation with visible and near infrared light to provide a non-invasive method of achieving spatial and temporal control. We have shown that the incorporation of gold nanoparticles (AuNP) within the vesicle membrane provides wavelength specific vesicle rupture at 532 nm. The wavelength dependence of our polymersome system can be shifted by altering the plasmonic mode of the nanoparticles by way of shape and composition.

Nanoparticle mediated release of polymersomes under single pulsed femto second irradiation

255th National Meeting (2018)

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