Photodynamic therapy ablates target cells with reactive oxygen species (ROS) generated upon light irradiation. Owing to the short lifetime (only tens of seconds) of ROS, photodynamic therapy works only within tens of nanometers around the photosensitizer, suggesting better spatiotemporal control than the closely related photothermal therapy. Clearly, to improve photodynamic therapy efficacy, the key is to precisely deliver the photosensitizer onto/into the target cells. However, current photodynamic systems rely on negative targeting or chemically attached active targeting moieties, which provides limited targeting efficacy and requires extra efforts on surface engineering, respectively. How to achieve photodynamic system that offers precise targeting without requiring extra efforts on surface engineering remains a challenge. Platelet membrane bears over-expressed P-selectin that specifically binds to CD44 up-regulated on the surface of cancer cells, and coating with platelet membrane endows a nanoparticle with long blood circulation lifetime. We hence coat a photodynamic nanoparticle with platelet membrane, in efforts to improve its targeting efficiency and consequent therapeutic efficacy. Results from cell studies and mouse models will be presented.

Precisely targeted photodynamic antitumor therapy by platelet membrane coated nanoparticle

255th National Meeting (2018)

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