Toll-Like Receptors (TLRs), which are part of the innate immune system are assembled on surfaces are tested for their ability to be exploited as biorecognition element. TLR-modified surfaces have been investigated using electrochemical techniques, such as cyclic voltammetry, electrochemical impedance spectroscopy and scanning electrochemical microscopy. These surfaces have been shown to be effective as sensors in detection of their relevant pathogen associated molecular patterns (PAMPs). TLR sensors represent a new class of broad spectrum approach, which is selective and non-specific, towards pathogens detection, including bacterial and viral species. These TLR proteins are best utilized as a group of components in a sensing platform. Therefore, a multiplex detection approach has been developed to provide such capability. The platform itself can be used with many other biological elements beyond TLR proteins. These sensors have great potential to be applied for environmental monitoring, clinical diagnostics and biological hazard controls.

Development of electrochemical multiplex 3-D sensors

255th National Meeting (2018)

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