The incorporation of motifs from natural proteins, such as collagen and resilin, into bioconjugates offers important opportunities in designing biomaterials with useful stimuli-responsive behavior. Their conjugation to polymers affords biomaterials with diverse properties responsive to multiple biologically relevant triggers. Conjugates are able to form a range of structures that modulate cell behavior and influence the retention and release of cargo, offering substantial improvement in cargo activity. These materials can be designed with microstructural heterogeneity as well as into particles that are useful in a variety of drug delivery approaches. The materials exhibit high cytocompatibility, can be used to modulate signaling by vascular cells, and to restore radial compliance in skeletonized vessels.

Phase-separating biopolymer conjugates to manipulate cell signaling and healing in cardiovascular tissues

255th National Meeting (2018)

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