Microgels derived from natural carbohydrates, xanthan gum (XG) and locust bean gum (LBG) were synthesized in water-in-oil microemulsion system. The morphological, thermal and structural characterizations were evaluated by using scanning electron microscope (SEM), thermogravimetric analysis (TGA), zeta potential measurements, and FT-IR spectroscopy. The prepared XG and LBG microgels were further modified with ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetraamine (TETA) and polyethyleneimine (PEI), respectively to introduce different number of amine functional groups into the microgel network. These chemically modified XG (mod-XG) and LBG (mod-LBG) microgels were tested against wide range of pathogenic bacteria by using macro dilution and disc diffusion techniques. Additionally, the bare and mod-XG and mod-LBG microgels were tested as potential drug carrier for active agent loading and release studies by using sodium diclofenac as a model drug. The blood compatibility and cytotoxicity of all the prepared microgels were also evaluated for potential biomedical applications.

Microgels from xanthan gum and locust bean gum for potential biomedical applications

255th National Meeting (2018)

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