Cisplatin and carboplatin are well-known platinum-based anticancer drugs that are used to treat various tumors. In this work, we have examined the modifications to DNA bases when cisplatin and carboplatin are present by employing Surface-Enhanced Raman Scattering (SERS). We will discuss the results of our experiments when DNA bases such as guanine and adenine are added to the drugs with different ratios and concentrations of the drugs and DNA. SERS spectra of guanine and guanine-drug complexes were obtained and compared to investigate the relative spectral changes. Our results suggest that when either cisplatin or carboplatin is added to guanine, it modifies the spectrum of guanine, particularly between 400 and 1800 frequencies.  We further obtained that either carboplatin or cisplatin does not significantly change the spectrum of adenine. Additional results and future experiments will be discussed in this presentation.<br/>

Understanding how cisplatin and carboplatin modify DNA bases

255th National Meeting (2018)

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