Coated medical devices that resist protein adhesion and bacterial contamination are highly desirable in the healthcare industry. In this work, an antifouling zwitterionic terpolymer, 2-methacryloyloxyethyl phosphorylcholine-co-butyl methacrylate-co-benzophenone (BPMPC), is covalently grafted to a nitric oxide (NO) releasing antimicrobial biomedical grade copolymer of silicone-polycarbonate-urethane, CarboSil, to significantly enhance the biocompatibility, non-specific protein repulsion and infection-resistant properties. Covalent bonding of the BPMPC is achieved through rapid UV-crosslinking, providing a stable, hydrophilic coating that has excellent durability over a period of several weeks under physiological conditions. S-nitroso-N-acetylpenicillamine (SNAP), the NO donor embedded into CarboSil, can release NO for extended periods with very low levels of leaching. The protein adsorption test results indicate a significant reduction (~84-93%) of protein adhesion. Moreover, bacteria tests show a 99.91 ± 0.06 % reduction of viable bacteria compared to control samples on Staphylococcus aureus. This work demonstrates a synergistic combination of both antifouling and antimicrobial in medical devices using NO donors and zwitterionic copolymers that can be covalently grafted to any polymer surface.

Covalent grafting of antifouling phosphorylcholine-based copolymers with antimicrobial nitric oxide releasing polymers to enhance infection-resistant properties of medical device coatings

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.