Most intramolecular chain end closing reactions leading to cyclic topologies rely on difunctional linear precursors, with compatibly reactive chain ends installed after the initial polymerization. We report strategies that use the native chain ends on the precursor that are present as a consequence of the atom transfer radical polymerization (ATRP), eliminating the need for chain end transformation and, in most cases, time consuming purification. The impact of solvent, radical trap, and additives on the yield of macrocycles is studied, with their effect varying depending on the specific class of polymer employed in the cyclization reaction.

Synthesis of cyclic polymers prepared directly from dibrominated precursors

255th National Meeting (2018)

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