Our focus is to use the thiol protecting group Allocam with two different projects. The first one is using allocam and different derivatives to use in a peptide to form the correct disulfide bond formation. This application is important to science specifically dealing with medicine. If we develop proper ways to fold proteins, we can use them in medicine for selectively binding to certain substrates. The second project focuses on Native Chemical Ligation which is the process of forming two peptides into one. With the use of allocam and its derivatives, we hope to be able to make a one pot solution of 3 or more peptides thereby allowing access to peptides that were inaccessible before to become achievable.

Strategic uses for the cysteine thiol protecting group, Allocam

255th National Meeting (2018)

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