Single-chain nanoparticles (SCNP) are a class of functional nanomaterial formed by the intramolecular cross-linking of polymer chains. Atom-transfer radical coupling (ATRC) is a promising synthetic route to SCNP and other specialized macromolecules; however, limitations in our current understanding of the key design parameters and ideal reaction conditions remain a barrier to the widespread implementation of this technique. To address these concerns, we have systematically examined the formation of SCNP by ATRC, varying the chemistry of the cross-linkable unit, length of the parent polymer, and ligand for the copper catalyst. The results of this study are expected to facilitate the use of ATRC chemistry in the design of both SCNP and a broad range of controlled nanoarchitectures.

Synthesis of single-chain nanoparticles under various ATRC reaction conditions

255th National Meeting (2018)

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