Natural products have been, and continue to be, a source of not only synthetic inspiration but also a vital pipeline for drug discovery. Even before the incarnation of the pharmaceutical industry as it exists today, total synthesis campaigns have been the supply lines for these compounds. Our laboratory is currently pursuing the total synthesis of multiple compounds in the efforts of discovering new bioactive compounds, said targets include: lagunamide C, myrothecol C, reniochalistatin E, brocazine F, balgacyclamide A, and uravetin. Each of these natural products possesses various biological activities, including: anti-cancer, anti-bacterial, and pesticidal. The total synthesis of each of these compounds are underway and are at various stages in their completion. Through these synthetic routes, the complex and synthetically versatile intermediates are being utilized as starting points for the construction of new chemical screening libraries and for new bioactive scaffold discovery. To be presented are new bioactive compounds accessed via the intermediates of our pursued total synthesis campaigns, their biological evaluation, and future directions and applications of each.

Bioactive molecule discovery via intermediates of total synthesis

255th National Meeting (2018)

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