T cells immunity is linked to complex system of cytokines that determine differentiation of naïve T cells into Th1, Th2, Th17, and Treg cells. Estrogen production or periods of elevated production have been correlated with anti-inflammatory state in which Th2 and Treg cells are upregulated. Such responses in the immune system are capable of supporting pre-cancerous activity. We are investigating the tie between the xenoestrogen compounds found in cosmetics, parabens, and their ability to regulate T cell immunity. Testing parabens and paraben derivatives with weaker estrogen receptor association will allow for a better understanding of the interplay between estrogen receptor activation and T cell Immunity.

What Influence does parabens and paraben derivatives have on T cell immunity?

255th National Meeting (2018)

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