We have developed a series of polymers that contain 1,2-oxazines within the polymer side chains. The oxazine units have been found to release HNO upon thermal activation, with concomitant release of an organic dye molecule that can be used as an indirect indicator for quantifying activation. The modular nature of the polymeric materials enabled access to random (statistical) and block copolymers via ring-opening metathesis polymerization. The resulting amphiphilic copolymers were found to yield robust hydrogels, shear thinning hydrogels, and micelles depending upon the copolymer structure and processing conditions. We will report on our efforts toward using these materials as a modular platform for the controlled release of HNO.

Amphiphilic block copolymers, hydrogels, and micelles for the controlled release of HNO

255th National Meeting (2018)

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