One of the draws of metal-organic framework (MOF) materials is that, while having several of the favorable properties of solid state materials, these materials can also undergo organic transformations much like small molecules in the solution phase. Via the process of post-synthesis modification (PSM), chemists can decorate the internal surfaces of these materials with whatever functional groups are most useful for a given application. Within the class of modified MOFs is a subset in which the frameworks are elaborated with two or more organic modifiers, resulting in cavities bearing multiple functional groups. These so-called multivariate MOFs are attractive for applications involving cooperative interactions within a single cavity, with the most notable application being enzyme mimetic catalysis.<br/><br/>Possessing pores of small-molecule sized dimensions, and composed of organic ligands that are highly tailorable, MOF-based catalysts are particularly attractive targets for use in selective transformations. This presentation will detail recent progress in constructing such multifunctional, enzyme mimetic MOF materials for application in transition metal- and organo-catalyzed, asymmetric transformations.

Synthetic strategies for constructing enzyme-inspired metal=organic framework materials

255th National Meeting (2018)

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