Microwave chemistry is a technique used to synthesize chemical compounds at quicker rates and higher controlled temperatures. Organic chemists have begun to rely on microwave chemistry because this method of synthesis is cleaner, faster and more convenient. In this present study, we have utilized microwave chemistry to carry out traditional organic reactions, such as Nucleophilic Aromatic Substitution reactions(SNAr). Recent studies have shown that benzimidazole molecules, such as Celecoxib, are effective anticancer agents. We are proposing to utilize microwave chemistry to carry out step one of a four-step synthesis producing benzimidazole molecules. The benzimidazole molecules will be evaluated as anticancer agents against triple negative breast cancer cell lines. We will use a Milestone START Microwave to carry out step 1: Nucleophilic Aromatic Substitution reaction. The starting compound, 1-fluoro-2-nitrobenzene reacts with various amine compounds to produce secondary amine products for step 1. The reactions are monitored by Thin Layer Chromatography (TLC) and purified using Isco Flash Column chromatography instrument. All products from step 1 will be used to carry out step 2 reaction. We have effectively utilized microwave chemistry to carry out Nucleophilic Aromatic Substitution reactions in a shorter time span producing better yields.

Nucleophilic aromatic substitution: Using microwave chemistry

255th National Meeting (2018)

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