Metal-Organic Frameworks (MOFs) are known to interact specifically with small molecules, thus MOFs are often used for the storage, capture and conversion of various gases. When come to the uptake of larger molecules, however, the interactions are complex and thus largely underdeveloped. In this talk we will demonstrate the pore size extension of MOFs into previously unattained regime (5-10 nm) through topological design and modular synthesis of organic links. A plethora of large molecules including drugs, single strand DNAs and proteins can be introduced into the MOF pore in a controllable manner. The precise interactions dialed-in between MOFs and guest molecules allow for high selectivity in their inclusion, excellent protection against degradation, and their programed release.

Mesoporous MOFs for DNA and protein Inclusion

255th National Meeting (2018)

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