The development of end-functionalized polysaccharides increases the utility of these naturally occurring and abundant polymeric materials by facilitating high yielding conjugation reactions with complementary polymers, small molecules, and biological targets. Herein we present the synthesis and characterization of a series of amine end-functionalized starches prepared by reductive amination. We demonstrate the utility of these macromolecular reagents in high-yielding conjugation reactions with a variety of electrophiles with an emphasis on activated esters.

Probing the reactivity of amine-end functionalized starches

255th National Meeting (2018)

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