Recent advent in the field of bio-inspired materials derived from the biological system as self-assembled biomaterials or in combination with biocompatible synthetic materials brings out the era of biomimetic technology, which can tackle with circulatory traffic and prevents nonspecific adsorption of the drug in the wide range of vital organs. The biomimetic cloaking of the synthetic nanoparticle using mammalian cell-ghosts has shown the installment of the biological complexity of the original cells thereby improving its therapeutic and diagnostic outcomes. Align towards this direction; we have developed a new class of bio-membrane integrated paramagnetic nanoparticles (BPN) which could communicate with an immune system for cooperative drug delivery. This new class of BPN is made up of synthetic materials such as phospholipid and/or biocompatible/biodegradable polymer integrate with cell membrane derive from blood pool cells followed by the insertion of gadolinium-based contrast agents. The engineered BPN shows successful retention of cell membrane-associated targeting protein on its surface. With its excellent biocompatibility, BNP shows a higher affinity towards cancer than normal cells as demonstrated by in vitro flow-passage assay, and exhibits enhanced tumor homing efficiency in-vivo with an extended plasma residence time of 18h. Along with targeting property, BNP exhibit high magnetic resonance relaxivity under magnetic resonance imaging which could serve as a promising contrast agent for diagnosis. In this talk, we will discuss the tackling of chemistry and engineering challenges to develop biomimetic long circulating nanosystem. The talk will be concluded with the properties and findings of engineered nanoconstructs including superior contrast enhancement properties for imaging and therapy.<br/>

Integration of bio-membrane in synthetic nanoparticle for diagnosis and therapy

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.