Trends in drug discovery are changing rapidly. During the past decade, terms “Scaffold hopping,” “Escape the Flatland” and “Conformational restriction” have been introduced, and have already found a huge practical application. Spiro compounds are especially interesting because they are intrinsically both - 3D-shaped and conformationally restricted. In this work, we have rationally designed, synthesized and applied a library of novel multifunctional spirocyclic cores for drug discovery. Details of the synthesis and application of the obtained compounds will be discussed.

Rapid access to novel multifunctional spirocyclic cores for drug discovery

255th National Meeting (2018)

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