Good laboratory practices for quantitative analysis is well established, but the development of QC/QA procedures for qualitative analysis has received little attention.  The use of high resolution accurate mass (HRAM) measurement to identify emerging contaminants, degradants of known contaminants, and true unknowns in the environment is becoming more prominent.   LC/HRAM MS needs procedures that provide assurance that the mass measurements are accurate.  In addition, the ability to correlate retention times and responses consistently over a long term study (weeks, months or even years), is necessary. Finally, whether employing non-targeted analysis using databases and libraries, or feature finding for unknowns, it is important to know that algorithmic settings (thresholds, tolerance boundaries, and filters) are appropriate values for the data sets collected. Appropriate selection of both internal standards and surrogate standards with the objective of fit for purpose can meet each of these important aspects of qualitative analysis.    This presentation will focus on the need to set both criteria and procedures that will provide assurance and control that experimental results are both valid and of the highest quality.<br/>

Quality control/quality assurance for qualitative analysis of environmental samples by LC/HRAM MS

255th National Meeting (2018)

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