Because of the continuing interest in multifunctional materials for biomedical applications, materials from natural sources or biological origin are on great demand. Due to the inherited biocompatibility and benefits, amino acid derived microgels possess great application potential in biomedical fields such as drug delivery, gene therapy, tissue engineering, bio-sensors, and so on. Here, a single step synthesis of amino acid based polymeric microgels based on l-lysine and arginine is reported by employing microemulsion polymerization technique. The prepared poly(amino acid) microgels are treated with HCl, and NaOH solution to demonstrate the variable zeta potential values of the prepared microgels. Moreover, these amino acids based microgels are shown to be chemically modifiable by using different modifying agents such as 1,3-propanesultone and alkyl halides of various chain lengths to induce different surface functionalities on the surface of colloidal microgels. Furthermore, the biodegradability, biocompatibility, hemolysis and antibacterial properties of the synthesized poly(amino acid) microgels are investigated. Also, the drug delivery and biomolecule separation potentials of these poly(amino acid) microgels are investigated.

Synthesis, characterization and some of applications of colloidal microgels from amino acids

255th National Meeting (2018)

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