Oligosaccharides, including human glycans, can engage in a myriad of recognition and signaling events that have potential therapeutic applications. Existing chemical methods to study saccharides are often applicable to selected problems and the key obstacles such as suboptimal selectivities in glycosylation reactions await broadly applicable solutions. In this presentation, I will describe our efforts focused on chemical synthesis of mammalian glycans, glycoconjugates, and small biologics and the use of these novel technologies for therapeutic benefits. Specifically, methods for stereoselective glycosylation, regioselective modifications of hydroxyl groups, and the synthesis of complex oligosaccharides of mammalian origin will be discussed.

Chemical tools and strategies to decipher the role of glycans in human disease

255th National Meeting (2018)

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