Direct measurement and stimulation of molecular, ionic, or electrophysiological activity is a staple of bioelectronic diagnosis and/or therapy. Such bi-directional interfacing can be enhanced by the low impedance imparted by organic electronic materials that show mixed conduction properties (both electronic and ionic transport). Many high performance bioelectronic devices are based on conducting polymers such as poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate), PEDOT:PSS. However, new structure-property and device-based design rules have led to the development of novel materials/formulations. The incorporation of glycol side chains into carefully selected backbone motifs, for example, has enabled a new class of high performance bioelectronic polymers that feature high volumetric capacitance, transconductance &gt;10mS (device dimensions ca. 5um), and steep subthreshold switching characteristics. We explore the implications of these new materials for biomolecular sensing and neural interfacing, including the effect of device operation regime on recording sensitivity and power consumption, and the role of molecular design on stability.

Designing organic mixed conductors for bioelectronic applications

255th National Meeting (2018)

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