This talk will describe the total synthesis of neurologically active terpenoid natural products using novel strategies and methodologies for step-efficient syntheses.  Methodological developments in the area of allyl-palladium catalysis will be described in detail that have allowed for alpha,beta-dehydrogenation of a variety of carbonyl compounds.  Unique strategies and key retrosynthetic disconnections are guided by computational investigation.

Total synthesis of neurologically active terpenoid natural products

255th National Meeting (2018)

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