Liposomes are important supramolecular lipid assemblies that have been shown to be effective for the encapsulation and delivery of drug cargo. To maximize the efficacy of liposomal drug delivery, important areas that need to be advanced are the ability to target liposomes to cells, drive membrane fusion, and trigger the release of encapsulated contents. In this presentation, we will focus on new strategies for triggering the reorganization of lipid self assembly to control membrane fusion and encapsulated content release. The design, synthesis and study of switchable lipid analogs that undergo chemical or conformational changes in the presence of external stimuli will be discussed. The switching of these lipids is designed to alter membrane properties and thereby drive content release and/or fusion.

Strategies for triggering liposome membrane fusion and content release

255th National Meeting (2018)

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