We have prepared and used novel trogers base (TB) decorated carbon nanoparticles CarboNano-Tweezers (CNTWZ) for breast cancer therapy applications. Considering that these particles act as nano-tweezers to twist the genomic DNA and induce cell inhibition cascade for cancer therapy, a series of biophysical and biological experiments were performed to achieve the feat. It was found that presence of TB facilitate nuclear localization of CNTWZs in breast caner cells while DNA interaction ability was dependent on isomeric form of TB used for preparation of CNTWZ. (-)-CNTWZ was found to be most effective in DNA ineteraction as revealed by UV-Vis, circular dichroism, gel electrophoresis and flow assisted cell scanning. This study facilitates the area of chirality based improvements in cancer thearpy at nanoscale level.

CarboNano-Tweezers for twisting DNA duplex in cancer cells

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.