The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2- and -OH that are associated with inflammatory response and cell death. Here, we report the synthesis of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus protecting inflammatory cells in a very low dose that is not possible with ceria nanoparticles. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two sepsis models, the lipopolysaccharide-induced endotoxemia and the cecal ligation and puncture-induced bacteremia model. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.

Ceria–Zirconia nanoparticles as an enhanced multi-antioxidant for sepsis treatment

255th National Meeting (2018)

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