Within the context of material sciences, researchers have shown that the combination of inorganic and organic chemistries in one single material, named metal-organic framework (MOF), offers structural designability at the molecular level together with tunable porosity and chemical functionalisability. In light of this, the main idea is to design hybrid nanomaterials based on MOFs, which could offer a new platform for biomedical applications. MOF nanoparticles (MOF NPs) combine the richness of bulk MOF chemistry with the surface- and size- dependent properties of the nanoworld.<br/>In this talk, we describe our research aiming at the establishment of material chemistry guidelines to engineer smart MOF nanoparticles (MOF NPs) able to unlock their potential for applications in the field of life sciences. To successfully achieve smart nanoMOFs, we aim to bring together five fields of expertise as illustrated up in the Figure. Special emphasis will be given to the characterization of MOF NPs, the MOF NPs’ external surface functionalization and their biological assessment. The highlight of this talk will be the presentation of a novel method “mass-correlation spectroscopy”, enabling the direct characterization of the density of NPs in suspension. Our results show that there is an interesting opportunity to tune the inner functionality of porous MOF NPs such that complex mixtures of solvents can be separated based on their permeation into the pores. The authors believe that establishing this measurement technique expands general understanding of the “porous nanoparticle” system and provides a new complementary method of nanoparticle characterization giving unique information on the interaction between particles and fluids, and on the effective composition of the particles in solution.

Beauty of metal-organic framework bulk chemistry combined with the fascinating world of nanoparticles

255th National Meeting (2018)

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