The hydroarylation of alkynes is an important reaction to generate aryl alkenes as building blocks for drug molecules or natural products. In contrast to the intramolecular reaction, the intermolecular hydroarylation is still a challenge of current research concerning chemo-, stereo-, and regioselectivity. Another limitation of the most catalytic systems is the narrow substrate scope. Electrophilic catalyst complexes of gold(I), palldium(II), and platinum(II) will be discussed and compared in their catalytic efficiency. The understanding of mechanistic details of the catalytic cycle and the function of co-catalysts such as acid and water are critical to optimize the reaction conditions and to improve the catalytic efficiency. Several other parameters, including reactor and solvent volume, have been studied to increase the reaction rate and the turn over number.

Hydroarylation of alkynes catalyzed by late transition metal complexes

255th National Meeting (2018)

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