Water is in many ways the ideal solvent—it is non-toxic, abundant, and renewable. Unfortunately, the water insolubility of organic compounds limits its ability to facilitate organic reactions. Recent work on using aqueous micellar solutions have helped remove the insolubility challenge. Non-polar organic compounds are entropically driven into the interior of the micelle and react. Flow chemistry has generated increased attention for organic synthesis, especially in the pharmaceutical industry. Compared to traditional batch chemistry, reactions conducted in flow occur faster, have greater temperature homogeneity, enable rapid screening of conditions, and allow reactions to occur safely under high pressure. We report the results of micelle-catalyzed metathesis reactions, in-flow. We successfully completed the ring-closing metathesis reaction of diethyl malonate using micellar catalysis, in-flow. The progress of micelle-catalyzed cross-metathesis reactions, in-flow, are also reported.

Micelle-catalyzed metathesis reactions in-flow

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.