The Boston University Center for Molecular Discovery (BU-CMD) lab focuses on creating diverse small molecule libraries for biological screening. One reaction strategy employed by the BU-CMD for small molecule diversification is the generation of oximes. The oxime functional group can be found in several different natural products and biologically active molecules. Oxime libraries can be readily synthesized by reacting alkoxyamine with either aldehydes or ketones. This project focused on the production of a small library of novel benzylic alkoxyamine building blocks, generated in two steps from the corresponding benzyl halide or benzyl alcohol.

Synthesis of hydroxylamine building blocks for oxime-based diversity libraries

255th National Meeting (2018)

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