Lipid-coated mesoporous silica nanoparticles (LC-MSNs, aka protocells), are an emerging class of nanocarriers. Protocells have been established as effective platforms for individual cell targeting and delivery needed for a variety of diseases including leukemia. As part of the protocell formation, MSN cores are made as a mean of encapsulating and releasing drugs. Dendritic large pore MSN cores are just one type of MSN that can be used as a mean of drug delivery in biological and medical applications.<br/>Synthetic conditions in a previously developed biphase synthesis are controlled so that we are able to fin-tune the pore size, condensation degree and yield of dendritic MSNs, altogether affecting the dissolution rate of the silica framework. Varied conditions include, pH of the mixture, thermal post-treatment conditions, stirring speed, catalyst type, and ratio of silica precursor in organic phase. The ability of mastering the structure characteristics on the basis of the aforementioned synthetic conditions is a key-feature for these MSNs to be used in bio-relevant conditions. Herein we show how the synergistic effect of lipid-coating removal and the degradation behavior in bio-relevant conditions of these large pores MSN are garnered to release payload of interest.

Fine-tuned nanoparticles synthesis for controlled pore size and condensation degree

255th National Meeting (2018)

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