Understanding the factors that govern self-assembly of metal-organic complexes and employing these techniques has enabled supramolecular chemists to develop a host of complex metal-organic architectures, many of which have subsequently been shown to have unique functions with potential utility in separation, drug delivery and stabilization applications. The majority of the examples reported however, are only soluble in organic solvents or host-guest binding is driven by hydrophobic interactions, making them unsuitable for binding of biological molecules that often have poor solubility in organic solvents or are degraded under such conditions.<br/>We describe the design of metal-organic constructs specifically optimized for biomolecule binding, with putative application in stabilization and delivery of biologically active proteins and optimization of enzyme reactors. <br/>

Designing functional supramolecules for biological applications

255th National Meeting (2018)

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