The increasing incidences of antibiotic resistance among pathogenic organisms in recent years has led to a greater interest in the development of new organometallic alternatives to already established antibiotics. Phosphonate molecules, including the antibiotic fosmidomycin, contain a relatively inert carbon–phosphorus bond, in comparison to the more labile phosphorus–oxygen bond of traditional classes of substrate. Vanadium compounds represent a potentially new area for the development of antibiotics. The reliable synthesis of vanadium–carbon bonds is vital for the development of vanadium based organometallic analogues of these antibiotics. A series of ligand substitution reactions with oxovanadium acetylacetonate and vanadyl trichloride were conducted with the goal of synthesizing these vanadium–carbon bonds. The nucleophiles used include Grignard and silyl reagents. Resulting complexes were characterized via Infrared and UV-vis spectroscopy, as well as 1H, 13C, and 51V nuclear magnetic resonance. Preliminary results indicate the presence of the desired organometallic product.

Synthesis of organometallic vanadium complexes as antibiotic analogues

255th National Meeting (2018)

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