We have used spectroscopic techniques to understand the interactions between carboplatin and a DNA oligomer COTAR 2: ATT AAT GGA TCC ATT AAT. This self-complementary sequence has been previously shown to bind to cobalt, [Co(NH3)2(OH2)2]+3 with high specificity and so is of interest because it contains a single G-G site. Both cisplatin and carboplatin, a derivative of cisplatin, are known for binding preferentially to G-G sites. These anti-tumor drugs are commonly used in chemotherapy treatments and are known to have adverse side effects. In order to improve treatment options, it’s necessary to understand the molecular basis of their interactions with DNA. The binding of carboplatin with COTAR 2 has been analyzed using Circular Dichroism (CD) and Surface − Enhanced Raman Scattering (SERS). The results of these studies will be presented and our current understanding of this interaction will be discussed.

Analysis of carboplatin and DNA interactions by spectroscopic techniques

255th National Meeting (2018)

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