The merger of transition metal catalysis and photoredox catalysis has enabled the discovery of a range of synthetically frustrating and hitherto unknown transformations. Use of carboxylic acids in particular have revolutionized the pharmaceutical industry due to their being relatively abundant native functionality that can be diversified to a variety of moieties. Building upon previous work, a novel decarboxylative C—C bond formation is accomplished via metallaphotoredox catalysis. This transformation is utilized for the late stage functionalization of over ten natural products and pharmaceutical drugs.

Metallaphotoredox catalysts for late stage functionalization

255th National Meeting (2018)

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