In this study, a strategy for catalytic C–H amination of alcohols has been developed. This method achieves β amination by installation of a radical chaperone that undergoes a selective 1,5-hydrogen atom transfer and subsequent amination. Under this protocol, β C–H bonds are selectively oxidized to generate a series of diverse 1,2-amino alcohols. Notably, under these mild catalytic conditions, many sensitive functionalities are tolerated, including electron-rich heterocycles.

Catalytic C–H amination of alcohols via radical relay chaperones

255th National Meeting (2018)

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