The monosaccharide N-acetylglucosamine (O-GlcNAc) modification is a post-translational modification on serine or threonine residues. This modification is common and important in many organisms and has been known to have implications in many biological processes, such as neural development, neurodegeneration, and cancer proliferation. Metabolic chemical reporters (MCRs) were used to discover and initially visualize O-GlcNAcylation in cells. We will use a combination of mutagenesis and chemical tools like MCRs to visualize and identify O-GlcNAcylated sites on caspase enzymes.

Optimizing methods for analyzing O-GlcNAc modifications

255th National Meeting (2018)

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