Ketones are important structural motifs in the field of organic chemistry. As a result, developing new catalytic methods to synthesize ketones from simple, inexpensive substrates are highly useful. Herein, we describe a new strategy that enables direct construction of aryl and alkyl ketones using aldehydes in combination with aryl and alkyl halides respectively via the synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This mild, operationally simple protocol transforms a wide variety of commercially available aldehydes, along with electronically diverse aryl, vinyl, and alkyl bromide, into the corresponding ketones in excellent yield. This C−H abstraction coupling technology has been successfully applied to the expedient synthesis of the medicinal agent haloperidol

Direct aldehyde C−H arylation and alkylation via metallaphotoredox catalysis

255th National Meeting (2018)

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