1,3-Amino alcohols are vital synthetic building blocks, as well as biologically important motifs. In this project, optimization of the Mannich reaction using aryl coupling partners and subsequent reduction to form 1,3-amino alcohols was explored. Specifically, the use of an iron Knolker-type complex to catalyze the transfer hydrogenation of Mannich bases (using isopropanol as the reductant) was explored. The use of this catalyst allowed for milder temperatures and pressures than are typically necessary this reaction. Ultimately, these conditions may allow for a more efficient synthesis of 1,3-amino alcohols and a wider substrate scope.

Iron-catalyzed reduction of Mannich bases

255th National Meeting (2018)

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