Regenerative medicine strategies for articular cartilage involves the development of constructs to support regeneration of damage and diseased tissues. Hydrogels are hydrophilic 3D polymer networks with high water content. Their water absorption and retention ability, biocompatibility, and tunable chemical and physical properties make these materials attractive for applications as scaffolds for articular cartilage. Herein, we present tunable polyglycidol oxime hydrogels that are a result of the combination of aminooxy and ketoester functionalized polyglycidol derivatives. The aminooxy and ketoester derivatives undergo a biorthogonal click reaction that results in a hydrogel exhibiting high strength and elasticity.

Polyglycidol-based hydrogels for applications in regenerative medicine

255th National Meeting (2018)

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