Pesticides, particulate matter, pharmaceuticals and other emerging contaminants continue to raise concerns about the impact they have on the environment and human health. Several are potent and biologically active chemicals that may disrupt the fatty acid metabolism and thereby change the metabolic phenotype associated with inflammation and other ailments. Bioactive lipid profiling using mass spectrometry methods has proven to be a powerful tool in analyses of fatty acid metabolites. Others have for instance used it for drug development and biomarker identification. In our own bioactive lipid profiling studies, we have generated new knowledge about how to indicate exposure to environmental contaminants, monitor postprandial inflammation and examine pain. Our studies represent a variety of contexts where exposure to an insult occurs, dietary challenge or environmental exposure. Independent of the source, we have shown that they all impact the bioactive lipid profiles. We have addressed the fundamental question of variation in bioactive lipid profiles and applied it in several human exposure scenarios, since it is desirable to design disease prevention and clinical care strategies that take individual variability into account. Ultimately, it is compelling to implement the concept of bioactive lipid profiling in the new era of precision medicine since it reflects the net result of environmental exposures, diet, and possibly other lifestyle factors, and thereby provides comprehensive metabolic phenotyping that can be associated to disorders on the individual level.<br/>

Bioactive lipid profiles as indicators of exposure

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.