Benzoxazinoids (BXs) are phytochemicals present in the cereals wheat and rye and in some medicinal plants. BXs function as plant defense compounds and recently they have attained focus as a health-promoting agent in humans. Several therapeutic effects such as anticancer, immunoregulatory, antimicrobial, weight reduction and central nervous system stimulation have been reported mainly in <i>in vitro</i> systems, but also in few cases in humans and animals. Further, different bioactive BX compounds and their conjugates have been reported in the plasma and urine of humans.<br/>Studies have suggested possible suppressive effect of BX on prostate cancer cells and recently the presence of BX has been detected in prostate biopsies from prostate cancer patients who volunteered in a one-week study in which they received rye-based commercial food with high concentrations of BXs. In the present study, we aim to investigate the suppressive effects of known BXs on prostate cancer cells using primary cells to avoid possible genetic drift in the commercial cell line. Primary prostate cancer cells have been established and exposed to different types of BX. The suppressive effect of BX on the prostate cancer cells will be measured as a difference in the expression of key genes involved in prostate cancer between the BX exposed and unexposed cancer cells using real time polymerase chain reaction (RT-PCR). The results from the RT-PCR analysis will be presented and discussed.<br/>

Suppressive effect of benzoxazinoids on prostate cancer cells

255th National Meeting (2018)

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