Acetaminophen is an active ingredient in prescription and over the counter analgesic drugs which is responsible for 50% of acute liver-failure (ALI) in Great Britain and the United States.  The current accepted mechanism of metabolism for acetaminophen-induced liver injury (AILI) involves the production of N-acetyl-p-benzoquinone imine (NAPQI) as a metabolite in the two-electron, p450 enzymatic oxidation.  However, evidence also supports a one-electron, enzymatic oxidation of acetaminophen.  This work will present high resolution ESR data of the enzymatically generated acetaminophen radical collected using the technique of immobilized enzyme – ESR (IE-ESR). In addition, oxidation products formed during the ESR experiments were analyzed via HPLC.

Revisiting the acetaminophen free radical

255th National Meeting (2018)

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