The goal of this series of experiments was to perform enantioselective catalytic cross-aldol reactions of aldehydes with proline as a catalyst. Propionaldehyde was used as the aldol donor and kept consistent throughout every trial. The electrophilic aldol acceptor aldehyde was changed between experiments to see how differences in R-group structures affected the reaction. Each experimental trial started with non-equivalent amounts of the aldol donor and acceptor. On later trials, the reaction was tested to see if closer equivalent molarities between the aldol donor and acceptor would produce a more pure product. This is relevant because it shows whether or not the proline catalyst is effective for multiple R-groups and whether equivalent or non-equivalent molarities are best at producing the desired product.

Enantioselective cross aldol reactions of aldehydes

255th National Meeting (2018)

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