The selective force from the ubiquitous use of antibacterial drugs over the past century has pressured bacteria to evolve resistance to their mechanisms of inhibition. This has created a need for the rapid development of new antibacterial drugs which employ new mechanisms of bacterial inhibition; one such innovation has been the development of Oxazolidinone antibacterials. These drugs target the ribosomes of the bacteria and inhibit protein synthesis, effectively causing cell death. A novel Oxazolidinone structure incorporating a fused cyclic ring system has displayed incredible potency against <i>Mycobacterium tuberculosis </i>and other drug-resistant strains of bacteria. This research is aimed at synthesizing a new compound based on this fused cyclic ring system which incorporates an amide functional group two carbons away from the ring with the hopes of increasing its effectivity as an antibacterial agent. This amide group was added for its hydrogen bonding capabilities to better bind to the ribosome and to hopefully become more water soluble. This derivative was attempted to be synthesized using an eight step synthesis; however, more recently, a four step synthesis was used which had been devised to synthesize Oxazolidinone derivatives whose functional groups contain acidic protons.<br/>

The synthesis of a novel oxazolidinone anitbacterial derived from dopamine

255th National Meeting (2018)

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