Amide bond formation is one of the most important reactions in chemistry. Nevertheless, developing reactions for the efficient synthesis of amides continues to be important, as the management of variables such as time, efficiency, temperature control, and pressure regulation remains challenging. Flow Chemistry can be a rapid and efficient method for the optimization of new reactions such as amide bond formation. Using the heterogeneous catalyst TiO<sub>2</sub>, we synthesized the amide functional group through a continuous flow system using propionitrile and various amines.

Synthesis of secondary amides from amine derivatives and propionitrile using a continuous flow process

255th National Meeting (2018)

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