It has been reported in the literature that Cu(II) metal complexes using thiosemicarbazone ligands can be used for inhibiting human topoisomerase IIα. In this research, acetyl-pyrazine methyl thiosemicarbazone [APZ-MTCS] and acetyl-pyrazine ethyl thiosemicarbazone [APZ-ETSC] ligands were synthesized and purified. After the synthesis and purification of [APZ-MTCS] and [APZ-ETSC] ligands, the 1H NMR and 13C NMR spectra were obtained using a new 500 MHz NMR spectrometer. Structural information was obtained by running 2D HSQC (heteronuclear single quantum coherence) 1H-13C NMR and HSQC 1H-15NNMR experiments, which provide evidence of our predicted structures. After the analysis was complete, we reacted the ligands with Pd(II) and two synthesis routes of Pt(II), using dichlorobis(benzonitrile) platinum(II) and potassium tetrachloroplatinate(II), to form their metal complexes. Similar NMR experiments were performed on the Pd(II) and Pt(II) complexes. This poster will present the synthesis of [APZ-MTSC] and [APZ-ETSC] and the reactions with their metal complexes, the NMR characterization, and discussion of the topoisomerase assay results.

Synthesis and NMR characterization of acetyl-pyrazine methyl thiosemicarbazone and acetyl-pyrazine ethyl-thiosemicarbazone ligands: Formation of their Pd(II) and Pt(II) complexes

255th National Meeting (2018)

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