Applications of nanoparticles (NPs) are rising exponentially in consumer products, biotechnology, and biomedicine. Hence, humans as well as the environment are increasingly exposed to NPs. Analogously, various (pathogenic) microorganisms are present in all major exposure and entry sites for NPs in the human body as well as in environmental habitats. However, the field has just started to explore the complex interplay of NPs with microbes, and its (patho)biological consequences.<br/>Based on recent insights, we here critically review our knowledge on the interaction of NPs with microbes and its analytical investigation. We comment on how the NPs' characteristics influence complex formation with microorganisms, present underlying physico-chemical forces, and provide examples how this knowledge can be used to rationally control NP-microbe interaction. We particularly will discusse the role of biomolecule coronas on NP-microbe crosstalk, and on impact of NP-microbe complex formation on the (patho)biological outcome and fate of microbial pathogens.

Relevance of the biomolecule corona for nanomaterial-microbe cross-talk

255th National Meeting (2018)

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